5/22/21 WHAT IS THE SCIENCE BEHIND MINDFULNESS? Negative emotions emerge from the parts of the brain called the amygdala and hippocampus, which are responsible for what’s known as “fight or flight” defenses. Fear and anger can cause us to act in ways that are erratic, frozen, hurtful or thoughtless. By avoiding a knee jerk response we allow the prefrontal cortex to rescue us, allowing for more thoughtful and reflective reactions. “Mindful practice,…, diminishes the reactivity from the amygdala and strengthens the prefrontal cortex (PFC). When the amygdala is calm, it